Fig. 22. PTEN modulates FLS proliferation and migration and may be closely associated with the AKT signaling pathway. (A) The protein level of p-AKT was analyzed by western blot in FLSs treated with bpv. (B) The protein level of p-AKT was analyzed by western blot in FLSs treated with PTEN-RNAi. (C) The protein level of p-AKT was analyzed by western blotting in FLSs treated with PTEN-GV141. (D) The protein level of p-AKT was analyzed by western blot in FLSs treated with 5-Aza. All values are expressed as the mean ± SD. ^## P<0.01 vs. normal group. ^**P<0.01 vs. AIA group.